Current topics in medicinal chemistry, 2015-01, Vol.14 (24), p.2759-2782
2015
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Details
- Autor(en) / Beteiligte
- Titel
- An overview of naturally occurring histone deacetylase inhibitors
- Ist Teil von
- Current topics in medicinal chemistry, 2015-01, Vol.14 (24), p.2759-2782
- Ort / Verlag
- United Arab Emirates
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1568-0266eISSN: 1873-4294DOI: 10.2174/1568026615666141208105614Titel-ID: cdi_pubmed_primary_25487010
- Format
- –
- Schlagworte
- Acetylation, Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Antineoplastic Agents, Phytogenic - pharmacology, Biological Products - chemistry, DNA Methylation, Drug Discovery, Epigenesis, Genetic, Heterochromatin - chemistry, Heterochromatin - metabolism, Histone Deacetylase Inhibitors - chemistry, Histone Deacetylase Inhibitors - isolation & purification, Histone Deacetylase Inhibitors - pharmacology, Histone Deacetylases - chemistry, Histone Deacetylases - genetics, Histone Deacetylases - metabolism, Humans, Isoenzymes - chemistry, Isoenzymes - genetics, Isoenzymes - metabolism, Models, Molecular, Neoplasms - drug therapy, Neoplasms - enzymology, Neoplasms - genetics, Neoplasms - pathology, Neurodegenerative Diseases - drug therapy, Neurodegenerative Diseases - enzymology, Neurodegenerative Diseases - genetics, Neurodegenerative Diseases - pathology, Neuroprotective Agents - chemistry, Neuroprotective Agents - isolation & purification, Neuroprotective Agents - pharmacology, Protein Processing, Post-Translational