Details

Autor(en) / Beteiligte

• Meiberth, Dix
• Scheef, Lukas
• Wolfsgruber, Steffen
• Boecker, Henning
• Block, Wolfgang
• Träber, Frank
• Erk, Susanne
• Heneka, Michael T
• Jacobi, Heike
• Spottke, Annika
• Walter, Henrik
• Wagner, Michael
• Hu, Xiaochen
• Jessen, Frank

Titel

Cortical thinning in individuals with subjective memory impairment

Ist Teil von

• Journal of Alzheimer's disease, 2015-01, Vol.45 (1), p.139

Ort / Verlag

Netherlands

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Elderly individuals with subjective memory impairment (SMI) report memory decline, but perform within the age-, gender-, and education- adjusted normal range on neuropsychological tests. Longitudinal studies indicate SMI as a risk factor or early sign of Alzheimer's disease (AD). There is increasing evidence from neuroimaging that at the group level, subjects with SMI display evidence of AD related pathology. This study aimed to determine differences in cortical thickness between individuals with SMI and healthy control subjects (CO) using the FreeSurfer environment. 110 participants (41 SMI/69 CO) underwent structural 3D-T1 MR imaging. Cortical thickness values were compared between groups in predefined AD-related brain regions of the medial temporal lobe, namely the bilateral entorhinal cortex and bilateral parahippocampal cortex. Cortical thickness reduction was observed in the SMI group compared to controls in the left entorhinal cortex (p = 0.003). We interpret our findings as evidence of early AD-related brain changes in persons with SMI.