Details

Autor(en) / Beteiligte

• Duarte, Angela P
• Marques, Cláudia D L
• Bortoluzzo, Adriana B
• Gonçalves, Célio R
• da Silva, José Antonio Braga
• Ximenes, Antonio Carlos
• Bértolo, Manoel B
• Ribeiro, Sandra Lúcia E
• Keiserman, Mauro
• Skare, Thelma L
• Carneiro, Sueli
• Menin, Rita
• Azevedo, Valderilio F
• Vieira, Walber P
• Albuquerque, Elisa N
• Bianchi, Washington A
• Bonfiglioli, Rubens
• Campanholo, Cristiano
• Carvalho, Hellen M S
• Costa, Izaias P
• Kohem, Charles L
• Leite, Nocy
• Lima, Sonia A L
• Meirelles, Eduardo S
• Pereira, Ivânio A
• Pinheiro, Marcelo M
• Polito, Elizandra
• Resende, Gustavo G
• Rocha, Francisco Airton C
• Santiago, Mittermayer B
• Sauma, Maria de Fátima L C
• Valim, Valéria
• Sampaio-Barros, Percival D
• Barros, Percival D Sampaio

Titel

Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort

Ist Teil von

• Revista brasileira de reumatologia, 2014-11, Vol.54 (6), p.424

Ort / Verlag

Brazil

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) and compare them with a group of adult-onset (≥ 16 years) SpA patients. Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE - Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset<16 years (JOSpA group) and age at onset ≥ 16 years (AOSpA group). Among the 1,424 patients, 235 presented disease onset before 16 years (16.5%). The clinical and epidemiologic variables associated with JOSpA were male gender (p<0.001), lower limb arthritis (p=0.001), enthesitis (p=0.008), anterior uveitis (p=0.041) and positive HLA-B27 (p=0.017), associated with lower scores of disease activity (Bath Ankylosing Spondylitis Disease Activity Index - BASDAI; p=0.007) and functionality (Bath Ankylosing Spondylitis Functional Index - BASFI; p=0.036). Cutaneous psoriasis (p<0.001), inflammatory bowel disease (p=0.023), dactylitis (p=0.024) and nail involvement (p=0.004) were more frequent in patients with adult-onset SpA. Patients with JOSpA in this large Brazilian cohort were characterized predominantly by male gender, peripheral involvement (arthritis and enthesitis), positive HLA-B27 and lower disease scores.