Details

Autor(en) / Beteiligte

• Lewis, Ian
• Schmid, Herbert A
• Kneuer, Rainer
• Hoyer, Daniel
• Silva, Antonio P
• Weckbecker, Gisbert
• Bruns, Christian
• Pless, Janos

Titel

SOM230: a new therapeutic modality for Cushing's disease

Ist Teil von

• Chimia, 2014-01, Vol.68 (7-8), p.483

Ort / Verlag

Switzerland

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• A rational drug design approach involving transposition of functional groups from SRIF into a reduced size cyclohexapeptide template has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin mimic which exhibits unique high affinity binding to human somatostatin receptors (sst1-5). This unique receptor subtype binding profile, in particular the exceptional high affinity binding to sst5, led to SOM230 being approved by EMEA and FDA in 2012 as the first effective pituitary directed therapeutic modality for Cushing's disease.