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The special role of inducible NO-synthase in the mechanism of rat coronary vessels tone regulation during immobilization stress, combined with diabetes mellitus
Ist Teil von
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014-04, Vol.100 (4), p.433
Ort / Verlag
Russia (Federation)
Erscheinungsjahr
2014
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Persistent hyperglycemia after intraperitoneal injection of streptozocin (50 mg/kg) to the rats prevents decrease of coronary vessels myogenic tone and myocardial contractility during subsequent 6-hr immobilization stress. The intensity of these abnormalities in all experimental groups is significantly reduced with the supplement of the perfusate with inducible NO-synthase (iNOS) selective blocker S-methylisothiourea. Similar rise of the NO2-/NO3- concentration in the rats' blood after "stress", "diabetes mellitus" and "diabetes mellitus + stress" combines with an increase of iNOS transcripts in the myocardium to 6, 5.8 and 51 times compared with control. These data testify to a substantial modification of the cells from coronary vessels in the presence of marked and persistent hyperglycemia. Inducible NO-synthase uncoupling caused by excessive formation of the reactive oxygen and nitrogen species in the myocardium may be one of number mechanisms responsible for such phenotypic vascular alteration in the "stress + diabetes mellitus" group.