Details

Autor(en) / Beteiligte

• Kotel'nikova, O V
• Alliluev, A P
• Drozhzhina, E Iu
• Koroleva, I S
• Sitnikova, E A
• Zinchenko, A A
• Gordeeva, E A
• Melikhova, T D
• Nokel', E A
• Zhigis, L S
• Zueva, V S
• Razguliaeva, O A
• Serova, O V
• Iagudaeva, E Iu
• Rumsh, L D

Titel

Protective properties of recombinant IgA1 protease from meningococcus

Ist Teil von

• Biomeditsinskaia khimiia, 2014-07, Vol.60 (4), p.479-486

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species - and type-specificity for mouse and human immunoglobulins. Mutant form, which did not exhibit enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C protecting the mice from lethal infection by living virulent culture of heterologous serogroups of meningococcus. Obtained results make it possible to consider IgA1 protease as a perspective preparation at the stages of development of polyvalent vaccine for protection the people from meningococcal infection of various etiology.