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Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2014-09, Vol.369 (1652), p.20130507
2014
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Autor(en) / Beteiligte
Titel
The role of long non-coding RNAs in neurodevelopment, brain function and neurological disease
Ist Teil von
  • Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2014-09, Vol.369 (1652), p.20130507
Ort / Verlag
England
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
  • Long non-coding RNAs (lncRNAs) are transcripts with low protein-coding potential that represent a large proportion of the transcriptional output of the cell. Many lncRNAs exhibit features indicative of functionality including tissue-restricted expression, localization to distinct subcellular structures, regulated expression and evolutionary conservation. Some lncRNAs have been shown to associate with chromatin-modifying activities and transcription factors, suggesting that a common mode of action may be to guide protein complexes to target genomic loci. However, the functions (if any) of the vast majority of lncRNA transcripts are currently unknown, and the subject of investigation. Here, we consider the putative role(s) of lncRNAs in neurodevelopment and brain function with an emphasis on the epigenetic regulation of gene expression. Associations of lncRNAs with neurodevelopmental/neuropsychiatric disorders, neurodegeneration and brain cancers are also discussed.

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