Details

Autor(en) / Beteiligte

• Bin-Nun, Alona
• Booms, Christina
• Sabag, Naama
• Mevorach, Refael
• Algur, Nurit
• Hammerman, Cathy

Titel

Rapid fecal calprotectin (FC) analysis: point of care testing for diagnosing early necrotizing enterocolitis

Ist Teil von

• American journal of perinatology, 2015-03, Vol.32 (4), p.337

Ort / Verlag

United States

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of this study is to compare fecal calprotectin (FC) levels as measured by a rapid FC assay with those measured by enzyme-linked immunosorbent assay (ELISA) from concurrent stool samples. We also attempted to demonstrate a correlation between elevated rapid assay FC levels and the presence of necrotizing enterocolitis (NEC) and to define a cutoff FC value which could serve as a basis for diagnosing NEC in the future. Stool samples were collected for FC analysis at 1 and 3 weeks postnatally and whenever there was clinical suspicion of NEC. Rapid assay FC levels were elevated with NEC (3,000 µg/g stool [2075,7875] vs. without (195 µg/g stool [110,440] p < 0.001); and were well correlated with ELISA FC levels (r(2) = 0.89). We present the first data showing that rapid assay FC levels are potentially useful in the bedside diagnosis of NEC.