Details

Autor(en) / Beteiligte

• Iasnetsov, V V
• Motin, V G
• Karsanova, S K
• Iasnetsov, Vic V
• Ivanov, Iu V
• Chel'naia, N A

Titel

Investigation into the vestibular protective properties of melatoninergic agents

Ist Teil von

• Aviakosmicheskaia i Äkologicheskaia meditsina, 2014, Vol.48 (2), p.31

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2014

Quelle

Universal Database of Russian Military & Security Periodicals

Beschreibungen/Notizen

• Experiments with rats showed that melatonin (2.5 mg/kg) produces a distinct vestibular protective effect excelling promethazine (50 mg/kg) as a reference agent, and also antidepressant agomelatine (5 mg/kg) as another melatoninergic agent. Lusindol, a blocker of MT1/MT2-receptors (2.5 mg/kg), and bicuculline (1.5 mg/kg), a specific GABA-receptors antagonist, weakened the melatonin effect significantly. The results testify mediation of the melatonin action by these receptors. Whole-cell patch clamp in an experiment with convoluted oblongata sections from white nonlinear infant male rats (14-d old) disclosed that melatonin (2 mM) inhibited drastically (29 +/- 3%) the excitatory postsynaptic current caused by depolarization step in neurons of the medial vestibular nucleus. Lusindol (0.1 mM) inhibited the effect of melatonin (2 mM) significantly (71 +/- 6%) which suggests involvement of melatonin MT1/MT2-receptors.