Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014-06, Vol.34 (6), p.875
2014
Volltextzugriff (PDF)

Details

Autor(en) / Beteiligte
Titel
Preparation and characterization of genipin-crosslinked silk fibroin/chitosan controlled-release microspheres
Ist Teil von
  • Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014-06, Vol.34 (6), p.875
Ort / Verlag
China
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
  • To investigate the property of genipin-crosslinked silk fibroin(SF)/chitosan(CS) microspheres for slow releasing of bovine serum albumin (BSA). BSA-loaded genipin-crosslinked SF/CS microspheres were prepared by emulsion cross-linking technique. The micropheres were observed for surface morphology and size distribution under scanning electron microscope (SEM), and X-ray diffractometry (XRD) and fourier transform infrared spectroscopy (FTIR) were used to analyze their structural characteristics. BCA method was used for determining the drug entrapment, loading rate and cumulative drug release in 21 days. The microspheres were spherical and showed a smooth surface with an average diameter of 7.84∓0.97 µm. The drug entrapment efficiency of the microspheres was (50.16∓4.32)% with a drug loading ratio of (1.25∓0.11)% and a cumulative release of the total drug of (75.2∓2.53)% in 21 days. Genipin-crosslinked SF/CS microspheres have a high drug entrapment efficiency and possess good capacity of sustained drug release.

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX