Details

Autor(en) / Beteiligte

• Baudin, Eric
• Habra, Mouhammed Amir
• Deschamps, Frederic
• Cote, Gilbert
• Dumont, Frederic
• Cabanillas, Maria
• Arfi-Roufe, J
• Berdelou, A
• Moon, Bryan
• Al Ghuzlan, Abir
• Patel, Shreyaskumar
• Leboulleux, Sophie
• Jimenez, Camilo

Titel

Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma

Ist Teil von

• European journal of endocrinology, 2014-09, Vol.171 (3), p.R111

Ort / Verlag

England

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Metastatic pheochromocytomas and paragangliomas (MPPs) present clinicians with three major challenges: scarcity, complexity of characterization, and heterogeneous behavior and prognosis. As with the treatment for all neuroendocrine tumors, the control of hormonal symptoms and tumor growth is the main therapeutic objective in MPP patients. A significant number of MPP patients still die from uncontrolled hormone secretion. In addition, the management of MPPs remains palliative. Steps forward include proper characterization of MPP patients at large cancer referral centers with multidisciplinary teams; improved strategies to stratify patients prognostically; and implementation of trials within national and international networks. Progress in the molecular characterization and staging of MPPs constitutes the basis for significant treatment breakthroughs.