Zhōnghuá zhŏngliú zázhì, 2014-03, Vol.36 (3), p.223
2014
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- Autor(en) / Beteiligte
- Titel
- Trastuzumab combined with chemotherapy in patients with HER2-positive chemo-refractory advanced gastric or gastro-esophageal junction adenocarcinoma
- Ist Teil von
- Zhōnghuá zhŏngliú zázhì, 2014-03, Vol.36 (3), p.223
- Ort / Verlag
- China
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To evaluate the efficacy and safety of trastuzumab combined with chemotherapy in the treatment for HER-2-positive chemo-refractory advanced gastric or gastro-esophageal junction adenocarcinoma. Twenty consecutive cases of chemo-refractory advanced gastric or gastro-esophageal junction adenocarcinoma treated in Peking University Cancer Hospital between 2009 June and 2013 August were included in this study. The patients with adenocarcinoma were previously confirmed and were eligible if their tumor showed overexpression of HER-2+++ by immunohistochemistry or HER-2 gene amplification-positive by FISH, and if they failed to at least one previous chemotherapy. Response and toxicities were evaluated with RECIST 1.0 and CTC AE 3.0 criteria. The twenty patients received trastuzumab plus second- or later-line chemotherapy, consisting of nine platinum with fluoropyrimidines, five paclitaxel with fluoropyrimidines, three fluoropyrimidines monotherapy, two irinotecan monotherapy, and one docetaxel monotherapy. In these 20
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 0253-3766Titel-ID: cdi_pubmed_primary_24785285
- Format
- –
- Schlagworte
- Adenocarcinoma - drug therapy, Adenocarcinoma - metabolism, Adenocarcinoma - secondary, Adenocarcinoma - surgery, Adult, Aged, Anorexia - chemically induced, Antibodies, Monoclonal, Humanized - administration & dosage, Antibodies, Monoclonal, Humanized - adverse effects, Antineoplastic Combined Chemotherapy Protocols - adverse effects, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Camptothecin - administration & dosage, Camptothecin - adverse effects, Camptothecin - analogs & derivatives, Cisplatin - administration & dosage, Cisplatin - adverse effects, Disease Progression, Disease-Free Survival, Drug Resistance, Neoplasm, Esophagogastric Junction, Fatigue - chemically induced, Female, Follow-Up Studies, Humans, Liver Neoplasms - drug therapy, Liver Neoplasms - secondary, Male, Middle Aged, Neutropenia - chemically induced, Paclitaxel - administration & dosage, Paclitaxel - adverse effects, Pyrimidines - administration & dosage, Pyrimidines - adverse effects, Receptor, ErbB-2 - metabolism, Remission Induction, Retrospective Studies, Stomach Neoplasms - drug therapy, Stomach Neoplasms - metabolism, Stomach Neoplasms - secondary, Stomach Neoplasms - surgery, Survival Rate, Trastuzumab