Details

Autor(en) / Beteiligte

• van Beurden, Yvette H
• Nijeboer, Petula
• Janssen, Johan
• Verbeek, Wieke H M
• Mulder, Chris J J

Titel

Diarrhoea and malabsorption due to olmesartan use

Ist Teil von

• Nederlands tijdschrift voor geneeskunde, 2014, Vol.158, p.A7370

Ort / Verlag

Netherlands

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• The differential diagnosis of diarrhoea in combination with villous atrophy is broad. Coeliac disease heads the list but medication-induced villous atrophy should also be taken into consideration. We report the case of a 63-year-old man presenting with recurrent secretory diarrhoea, acute renal failure and metabolic acidosis. Initial work-up revealed total villous atrophy (Marsh stage IIIC) with intraepithelial lymphocytosis. A gluten-free diet did not have any effect on the diarrhoea. During several periods of hospitalization antihypertensive medications were temporarily stopped due to dehydration; this resulted in reduction of his symptoms. Eventually an association between the enteropathy and the antihypertensive olmesartan was suspected. Indeed, permanent withdrawal of olmesartan resulted in permanent clinical improvement. Olmesartan is frequently prescribed in the Netherlands and it should be included in the differential diagnosis of diarrhoea accompanying villous atrophy.