Details

Autor(en) / Beteiligte

• Telek, B
• Kiss, A
• Pecze, K
• Rák, K

Titel

Cytochemical studies in the blastic transformation of chronic granulocytic leukaemia

Ist Teil von

• Folia haematologica (Leipzig, Germany : 1928), 1989, Vol.116 (1), p.49

Ort / Verlag

Germany

Erscheinungsjahr

1989

Quelle

MEDLINE

Beschreibungen/Notizen

• The cytochemical features of blast cells were studied in 45 patients with blastic phase of chronic granulocytic leukaemia. Various degrees of Sudan black B positivity was characteristic of myeloblastic transformation (23 patients), while in the medullary blast cells of nine patients with myelomonocytic transformation the alpha-naphthyl-acetate esterase showed intensive activity. In two cases the demonstrability of beta-thromboglobulin and factor VIII-related antigen in blast cells showing otherwise PAS, acid phosphatase and alpha-naphthyl-acetate esterase activity referred to megakaryocytic transformation. In six patients with lymphoid blast crisis proliferation of the Sudan negative blast cells with different granular PAS, acid phosphatase and/or beta-glucuronidase positivity was demonstrated. In five cases the cytochemical findings of leukaemic cells indicated biphenotypic and mixed transformation, respectively.