Details

Autor(en) / Beteiligte

• Kuchenbecker, James A
• Greenwald, Scott H
• Neitz, Maureen
• Neitz, Jay

Titel

Cone-isolating ON-OFF electroretinogram for studying chromatic pathways in the retina

Ist Teil von

• Journal of the Optical Society of America. A, Optics, image science, and vision, 2014-04, Vol.31 (4), p.A208

Ort / Verlag

United States

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• The electroretinogram (ERG) provides information about outer retina function in both clinical and research applications. ERG components elicited by light increments and decrements can be separated using a long-flash paradigm in which periods of light ON and OFF are alternated. Here, the ON-OFF ERG is combined with a silent substitution technique to elicit responses from individual cone photoreceptor classes by modulating the intensities of three color lights between the two periods. The results focus on the short wavelength (S) cone pathways since they are vulnerable to disease and because there are many unanswered questions about S-cone ON and OFF circuitry.