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Cone-isolating ON-OFF electroretinogram for studying chromatic pathways in the retina
Ist Teil von
Journal of the Optical Society of America. A, Optics, image science, and vision, 2014-04, Vol.31 (4), p.A208
Ort / Verlag
United States
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
The electroretinogram (ERG) provides information about outer retina function in both clinical and research applications. ERG components elicited by light increments and decrements can be separated using a long-flash paradigm in which periods of light ON and OFF are alternated. Here, the ON-OFF ERG is combined with a silent substitution technique to elicit responses from individual cone photoreceptor classes by modulating the intensities of three color lights between the two periods. The results focus on the short wavelength (S) cone pathways since they are vulnerable to disease and because there are many unanswered questions about S-cone ON and OFF circuitry.