Details

Autor(en) / Beteiligte

• Boucheron, Nicole
• Tschismarov, Roland
• Goeschl, Lisa
• Moser, Mirjam A
• Lagger, Sabine
• Sakaguchi, Shinya
• Winter, Mircea
• Lenz, Florian
• Vitko, Dijana
• Breitwieser, Florian P
• Müller, Lena
• Hassan, Hammad
• Bennett, Keiryn L
• Colinge, Jacques
• Schreiner, Wolfgang
• Egawa, Takeshi
• Taniuchi, Ichiro
• Matthias, Patrick
• Seiser, Christian
• Ellmeier, Wilfried

Titel

CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Ist Teil von

• Nature immunology, 2014-05, Vol.15 (5), p.439

Ort / Verlag

United States

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown. Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of this process. Loss of HDAC1 and HDAC2 during late T cell development led to the appearance of major histocompatibility complex (MHC) class II-selected CD4(+) helper T cells that expressed CD8-lineage genes such as Cd8a and Cd8b1. HDAC1 and HDAC2-deficient T helper type 0 (TH0) and TH1 cells further upregulated CD8-lineage genes and acquired a CD8(+) effector T cell program in a manner dependent on Runx-CBFβ complexes, whereas TH2 cells repressed features of the CD8(+) lineage independently of HDAC1 and HDAC2. These results demonstrate that HDAC1 and HDAC2 maintain integrity of the CD4 lineage by repressing Runx-CBFβ complexes that otherwise induce a CD8(+) effector T cell-like program in CD4(+) T cells.