Clinics in perinatology, 2014-03, Vol.41 (1), p.47-67
2014
Details
- Autor(en) / Beteiligte
- Titel
- Pathogenesis and Prevention of Intraventricular Hemorrhage
- Ist Teil von
- Clinics in perinatology, 2014-03, Vol.41 (1), p.47-67
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of preventing IVH. Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0095-5108eISSN: 1557-9840DOI: 10.1016/j.clp.2013.09.007Titel-ID: cdi_pubmed_primary_24524446
- Format
- –
- Schlagworte
- Angiogenesis, Astrocytes, Astrocytes - metabolism, Basement Membrane - metabolism, Cerebral Hemorrhage - physiopathology, Cerebral Hemorrhage - prevention & control, Cerebral Ventricles - blood supply, Cerebral Ventricles - physiopathology, Cerebrovascular Circulation - physiology, Fibronectins - metabolism, General Nursing, Germinal matrix hemorrhage, Glial Fibrillary Acidic Protein - metabolism, Glucocorticoids, Glucocorticoids - therapeutic use, Humans, Indomethacin, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases - physiopathology, Infant, Premature, Diseases - prevention & control, Intraventricular hemorrhage, Neovascularization, Physiologic - physiology, Pericytes, Pericytes - metabolism, Premature infants