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Impact of L-arginin immobilized on surgical suture material on the oxidation metabolism in the periwound tissues of the operated small bowel
Ist Teil von
Klinična hìrurgìâ (Kiïv), 2013-09 (9), p.66
Ort / Verlag
Ukraine
Erscheinungsjahr
2013
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In experiment on 50 white rats of the Wistar line there was investigated the impact of L-arginin, while its systemic and local (in a content of synthetic absorbable suture material) application, on the indices of a free-radical and bioenergetics processes in a small bowel tissues after experimental enterotomy. There was shown, that as a consequence of L-arginin application there in periwound tissues of a small bowel on the third postoperative day the superoxidal anion-radical production and the processes of peroxidal oxidation of lipids (POL) go down, what prophylaxes the antioxidant potential lowering and a content of the macroergic complexes and energetic potential enhancement. The investigation results witness, that the L-arginin efficacy substantiates the need for creation of a new pharmacologically modified synthetic suture material, which prophylaxes the free-radical and hypoxic necrobiosis and stimulates healing processes in a surgical wound.