Details

Autor(en) / Beteiligte

• McLellan, Jason S
• Ray, William C
• Peeples, Mark E

Titel

Structure and function of respiratory syncytial virus surface glycoproteins

Ist Teil von

• Current topics in microbiology and immunology, 2013, Vol.372, p.83

Ort / Verlag

Germany

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of infection. G targets the ciliated cells of the airways, and F causes the virion membrane to fuse with the target cell membrane. The F protein is the major target for antiviral drug development, and both G and F glycoproteins are the antigens targeted by neutralizing antibodies induced by infection. In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.