Nature immunology, 2013-12, Vol.14 (12), p.1294
2013
Details
- Autor(en) / Beteiligte
- Titel
- The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin
- Ist Teil von
- Nature immunology, 2013-12, Vol.14 (12), p.1294
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tissue-resident memory T cells (T(RM) cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-β (TGF-β) was required for the formation of these long-lived memory cells. Notably, differentiation into T(RM) cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1529-2916DOI: 10.1038/ni.2744Titel-ID: cdi_pubmed_primary_24162776
- Format
- –
- Schlagworte
- Animals, Antigens, CD - genetics, Antigens, CD - immunology, Antigens, CD - metabolism, Antigens, Differentiation, T-Lymphocyte - genetics, Antigens, Differentiation, T-Lymphocyte - immunology, Antigens, Differentiation, T-Lymphocyte - metabolism, CD8-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - metabolism, CD8-Positive T-Lymphocytes - virology, Cell Differentiation - genetics, Cell Differentiation - immunology, Flow Cytometry, Herpes Simplex - immunology, Herpes Simplex - virology, Herpesvirus 1, Human - immunology, Herpesvirus 1, Human - physiology, Host-Pathogen Interactions - immunology, Immunologic Memory - immunology, Integrin alpha Chains - genetics, Integrin alpha Chains - immunology, Integrin alpha Chains - metabolism, Interleukin-15 - genetics, Interleukin-15 - immunology, Interleukin-15 - metabolism, Lectins, C-Type - genetics, Lectins, C-Type - immunology, Lectins, C-Type - metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Knockout, Mice, Transgenic, Oligonucleotide Array Sequence Analysis, Protein-Serine-Threonine Kinases - genetics, Protein-Serine-Threonine Kinases - immunology, Protein-Serine-Threonine Kinases - metabolism, Receptors, Immunologic - genetics, Receptors, Immunologic - immunology, Receptors, Immunologic - metabolism, Receptors, Transforming Growth Factor beta - genetics, Receptors, Transforming Growth Factor beta - immunology, Receptors, Transforming Growth Factor beta - metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction - genetics, Signal Transduction - immunology, Skin - immunology, Skin - metabolism, Skin - virology, Transcriptome - genetics, Transcriptome - immunology