Details

Autor(en) / Beteiligte

• Costa, Ana Sofia
• Reich, Arno
• Fimm, Bruno
• Ketteler, Simon Thomas
• Schulz, Joerg Bernhard
• Reetz, Kathrin

Titel

Evidence of the sensitivity of the MoCA alternate forms in monitoring cognitive change in early Alzheimer's disease

Ist Teil von

• Dementia and geriatric cognitive disorders, 2014-02, Vol.37 (1-2), p.95-103

Ort / Verlag

Switzerland

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• There is an increasing interest in using the Montreal Cognitive Assessment (MoCA) test as a monitoring tool in Alzheimer's disease (AD) in both research and clinical settings. Our aim was to investigate the utility of alternate forms of the MoCA in detecting cognitive deterioration in a sample of early AD patients followed longitudinally in an outpatient memory clinic. Twenty-five patients with early-stage AD (prodromal or mild dementia) were administered the original version and one of two previously validated alternate forms of the MoCA within an interval of about 1 year. The decline over time and the rate of change of the MoCA were compared to the total score of a standardized neuropsychological assessment battery (Consortium to Establish a Registry of Alzheimer's Disease; CERAD-Plus). Responsiveness to change was determined by calculating standard response means and the respective effect sizes. Sixty percent of the sample showed a clinical decline on the clinical dementia rating (CDR) scale. There was significant deterioration in the MoCA and CERAD total scores. The results demonstrate that the MoCA is capable of detecting change over time and seems to be a valid tool with small to moderate sensitivity for monitoring cognitive change in early AD.