Details

Autor(en) / Beteiligte

• Holt, Kathryn E.
• Vu Thieu Nga, Tran
• Thanh, Duy Pham
• Vinh, Ha
• Kim, Dong Wook
• Vu Tra, My Phan
• Campbell, James I.
• Van Minh Hoang, Nguyen
• Vinh, Nguyen Thanh
• Van Minh, Pham
• Thuy, Cao Thu
• Nga, Tran Thi Thu
• Thompson, Corinne
• Thi Ngoc Dung, Tran
• Thi Khanh Nhu, Nguyen
• Vinh, Phat Voong
• Thi Ngoc Tuyet, Pham
• Le Phuc, Hoang
• Thi Nam Lien, Nguyen
• Phu, Bui Duc
• Thi Thuy Ai, Nguyen
• Tien, Nguyen Manh
• Dong, Nguyen
• Parry, Christopher M.
• Hien, Tran Tinh
• Farrar, Jeremy J.
• Parkhill, Julian
• Dougan, Gordon
• Thomson, Nicholas R.
• Baker, Stephen

Titel

Tracking the establishment of local endemic populations of an emergent enteric pathogen

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (43), p.17522-17527

Ort / Verlag

United States: NATIONAL ACADEMY OF SCIENCES

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.