Xi bao yu fen zi mian yi xue za zhi, 2013-08, Vol.29 (8), p.850
2013
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- Autor(en) / Beteiligte
- Titel
- CD28 expression on CD4(+);T cells and its relationship with IFN-γ/IL-10 ratio in patients with primary immune thrombocytopenia
- Ist Teil von
- Xi bao yu fen zi mian yi xue za zhi, 2013-08, Vol.29 (8), p.850
- Ort / Verlag
- China
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate CD28 expression on CD4(+);T cells and its relationship with IFN-γ/IL-10 ration in patients with primary immune thrombocytopenia (ITP) before and after treatment. The expression of CD4(+);CD28(+); was detected by flow cytometry, the levels of IFN-γ and IL-10 were determined by double-antibody sandwich ELISA and platelet count was tested by blood cells automatical counter in peripheral blood of 30 patients with ITP before and after glucocorticoid treatment and 26 cases of normal controls. Then the correlations between the outcomes were analyzed. The expression of CD4(+);CD28(+); of ITP patients before treatment was higher than that of the normal control group (P<0.05), however, after treatment the expression between the two groups had no statistical difference (P>0.05). Compared with the control group, the ITP patients before treatment showed the significantly higher level of IFN-γ and the significantly decreased level of IL-10, and the ratio of IFN-γ/IL-10 was significantly raised (P<0.01); whil
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1007-8738Titel-ID: cdi_pubmed_primary_23948413
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, CD28 Antigens - biosynthesis, CD28 Antigens - immunology, CD4-Positive T-Lymphocytes - immunology, CD4-Positive T-Lymphocytes - metabolism, Female, Humans, Interferon-gamma - immunology, Interferon-gamma - metabolism, Interleukin-10 - immunology, Interleukin-10 - metabolism, Male, Middle Aged, Thrombocytopenia - blood, Thrombocytopenia - immunology, Thrombocytopenia - metabolism, Young Adult