Details

Autor(en) / Beteiligte

• Satpathy, Ansuman T
• Briseño, Carlos G
• Lee, Jacob S
• Ng, Dennis
• Manieri, Nicholas A
• Kc, Wumesh
• Wu, Xiaodi
• Thomas, Stephanie R
• Lee, Wan-Ling
• Turkoz, Mustafa
• McDonald, Keely G
• Meredith, Matthew M
• Song, Christina
• Guidos, Cynthia J
• Newberry, Rodney D
• Ouyang, Wenjun
• Murphy, Theresa L
• Stappenbeck, Thaddeus S
• Gommerman, Jennifer L
• Nussenzweig, Michel C
• Colonna, Marco
• Kopan, Raphael
• Murphy, Kenneth M

Titel

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

Ist Teil von

• Nature immunology, 2013-09, Vol.14 (9), p.937-948

Ort / Verlag

United States

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Defense against attaching-and-effacing bacteria requires the sequential generation of interleukin 23 (IL-23) and IL-22 to induce protective mucosal responses. Although CD4(+) and NKp46(+) innate lymphoid cells (ILCs) are the critical source of IL-22 during infection, the precise source of IL-23 is unclear. We used genetic techniques to deplete mice of specific subsets of classical dendritic cells (cDCs) and analyzed immunity to the attaching-and-effacing pathogen Citrobacter rodentium. We found that the signaling receptor Notch2 controlled the terminal stage of cDC differentiation. Notch2-dependent intestinal CD11b(+) cDCs were an obligate source of IL-23 required for survival after infection with C. rodentium, but CD103(+) cDCs dependent on the transcription factor Batf3 were not. Our results demonstrate a nonredundant function for CD11b(+) cDCs in the response to pathogens in vivo.