Details

Autor(en) / Beteiligte

• Asano, Satoru
• Takemura, Tamiko
• Katoh, Keiichi
• Taneda, Masuzoh
• Kitagawa, Masanobu

Titel

Epithelial regeneration after diffuse alveolar damage in relation to underlying disease and DAD stage: an autopsy study

Ist Teil von

• Journal of Medical and Dental Sciences, 2011, Vol.58(4), pp.113-121

Ort / Verlag

Japan: Tokyo Medical and Dental University (TMDU)

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• This study was conducted to characterize thedistribution of epithelial regeneration in lungs withdiffuse alveolar damage (DAD) and to ascertainwhether epithelial regeneration is associated withthe underlying disease and/or DAD stage. Methods:Lung specimens obtained at autopsy from 18patients were studied using p63, PE-10 and Ki-67immunostaining. The patients were categorizedinto two groups: patients with acute exacerbationof idiopathic pulmonary fibrosis (AE-IPF; IPF group)and patients without IPF (non-IPF group). Results:p63-positive cells were mostly observed in thealveolar ducts. No significant difference in theappearance of the p63-positive cells was observedbetween the IPF and non-IPF groups or betweenthe exudative and the proliferative stages. PE-10-positive cells were observed in the alveoli. Thenumber of PE-10-positive cells was significantlyhigher during the proliferative stage than duringthe exudative stage. However, p63-positive cellsand PE-10-positive cells appeared at day 6 in theearliest case during the exudative stage and Ki-67-positive cells were observed during theexudative stage. Conclusion: Epithelialregeneration was not associated with theunderlying disease. This study revealed thatregenerative epithelial cells appeared at day 6during the exudative stage and that the number oftype Ⅱ pneumocytes increased significantly duringthe proliferative stage.