Details

Autor(en) / Beteiligte

• Acunzo, Mario
• Romano, Giulia
• Palmieri, Dario
• Laganá, Alessandro
• Garofalo, Michela
• Balatti, Veronica
• Drusco, Alessandra
• Chiariello, Mario
• Nana-Sinkam, Patrick
• Croce, Carlo M.

Titel

Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8573-8578

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• In the past decade, we have observed exciting advances in lung cancer therapy, including the development of targeted therapies. However, additional strategies for early detection and tumor-based therapy are still essential in improving patient outcomes. EGF receptor (EGFR) and MET (the receptor tyrosine kinase for hepatocyte growth factors) are cell-surface tyrosine kinase receptors that have been implicated in diverse cellular processes and as regulators of several microRNAs (miRNAs), thus contributing to tumor progression. Here, we demonstrate a biological link between EGFR, MET, and the miRNA cluster 23a∼27a∼24–2 . We show that miR-27a regulates MET, EGFR, and Sprouty2 in lung cancer. In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both MET and EGFR. Thus, we propose a mechanism for MET and EGFR axis regulation that may lead to the development of therapeutics in lung cancer.