Details

Autor(en) / Beteiligte

• Helmrich, Anne
• Ballarino, Monica
• Nudler, Evgeny
• Tora, Laszlo

Titel

Transcription-replication encounters, consequences and genomic instability

Ist Teil von

• Nature structural & molecular biology, 2013-04, Vol.20 (4), p.412-418

Ort / Verlag

United States

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we summarize strategies evolved in bacteria and eukaryotes to minimize the consequences of collisions, including R-loop formation and topological stresses.