Details

Autor(en) / Beteiligte

• Hartlapp, Ingo
• Müller, Justus
• Kenn, Werner
• Steger, Ulrich
• Isbert, Christoph
• Scheurlen, Michael
• Germer, Christoph-Thomas
• Einsele, Hermann
• Kunzmann, Volker

Titel

Complete pathological remission of locally advanced, unresectable pancreatic cancer (LAPC) after intensified neoadjuvant chemotherapy

Ist Teil von

• Oncology research and treatment, 2013, Vol.36 (3), p.123-125

Ort / Verlag

Switzerland

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Unresectable locally advanced pancreatic cancer (LAPC) has an extremely poor prognosis. Results of neoadjuvant (radio-)chemotherapy approaches aiming at achieving resectability are currently not satisfactory. We report the case of a 67-year-old woman with histologically confirmed pancreas carcinoma that was not resectable on first surgical exploration who achieved a well-documented complete pathological remission (pCR). The carcinoma became resectable after consecutive neoadjuvant treatment with nanoparticle albumin-bound (nab)-paclitaxel/gemcitabine and FOLFIRINOX chemotherapy regimens. This is the first reported LAPC case in which neoadjuvant chemotherapy alone has been shown to lead to demonstrated pCR. CA19-9 levels, but not imaging criteria, were useful for response prediction and timing of the Whipple's procedure. The findings in this case suggest possible conceptual changes in the treatment approach for LAPC, and indicate that the new effective chemotherapy regimens should be integrated into clinical trials for LAPC.