Advances in experimental medicine and biology, 2013, Vol.775, p.135
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Regulation of taurine release in the hippocampus of developing and adult mice
- Ist Teil von
- Advances in experimental medicine and biology, 2013, Vol.775, p.135
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Taurine release in mouse hippocampal slices is regulated by several neurotransmitter receptor systems. The ionotropic glutamate receptors and the adenosine receptor A(1) are the most effective. The effect of N-methyl-D-aspartate receptors is mediated via activation of the pathway involving nitric oxide and 3',5'-cyclic guanosine monophosphate. The activation of excitatory amino acid receptors causes at the same time an increase in taurine release. The activation of adenosine A(1) receptors also potentiates taurine release. The taurine released may counteract any excitotoxic effects of glutamate, particularly in the developing hippocampus.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0065-2598DOI: 10.1007/978-1-4614-6130-2_11Titel-ID: cdi_pubmed_primary_23392930
- Format
- –
- Schlagworte
- Aging - drug effects, Aging - metabolism, Animals, Hippocampus - drug effects, Hippocampus - growth & development, Hippocampus - secretion, Hydroxylamine - pharmacology, In Vitro Techniques, Mice, Purinergic P1 Receptor Agonists - pharmacology, Receptor, Adenosine A1 - metabolism, Receptors, Ionotropic Glutamate - agonists, Receptors, Ionotropic Glutamate - antagonists & inhibitors, Receptors, Ionotropic Glutamate - metabolism, Taurine - secretion, Tritium, Xanthines - pharmacology