Details

Autor(en) / Beteiligte

• Bosch, Ronald J
• Zhang, Xinyan
• Sandler, Netanya G

Titel

Study design issues in evaluating immune biomarkers

Ist Teil von

• Current opinion in HIV & AIDS, 2013-03, Vol.8 (2), p.147

Ort / Verlag

United States

Erscheinungsjahr

2013

Link zum Volltext

Beschreibungen/Notizen

• The dramatic increase in the number and type of immune biomarkers that can be measured, particularly those assessing immune activation, has led to numerous investigations in HIV-infected individuals to explore pathogenesis and to assess therapeutic interventions that aim to attenuate immune activation. An overview is provided on study designs and related statistical and operational issues relevant to these investigations. Cohort studies and nested case-control studies within these cohorts have identified multiple biomarkers that are associated with an increased risk of disease. Early-stage clinical trials of therapies to address these risks in HIV-infected individuals with viral suppression on antiretroviral therapy are a substantial focus of current HIV research. Appropriate study design is essential in biomarker research.