Details

Autor(en) / Beteiligte

• Fatahzadeh, Mahnaz, DMD
• Schlecht, Nicolas F., PhD, MSc
• Chen, Zigui
• Bottalico, Danielle
• McKinney, Sharod
• Ostoloza, Janae
• Dunne, Anne
• Burk, Robert D., MD

Titel

Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection

Ist Teil von

• Oral surgery, oral medicine, oral pathology and oral radiology, 2013-04, Vol.115 (4), p.505-514

Ort / Verlag

United States: Mosby, Inc

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To evaluate reproducibility of oral rinse self-collection for human papillomavirus (HPV) detection and investigate associations between oral HPV, oral lesions, immune and sociodemographic factors, we performed a cross-sectional study of older adults with human immunodeficiency virus (HIV) infection. Study Design We collected oral rinse samples from 52 subjects at 2 different times of day, followed by an oral examination and interview. We identified HPV with the use of polymerase chain reaction platforms optimized for detection of mucosal and cutaneous types. Results Eighty-seven percent of individuals had oral HPV, of which 23% had oncogenic alpha, 40% had nononcogenic alpha, and 46% had beta or gamma HPV. Paired oral specimens were concordant in all parameters tested. Significant associations observed for oral HPV with increased HIV viral load, hepatitis C seropositivity, history of sexually transmitted diseases, and lifetime number of sexual partners. Conclusions Oral cavity may be a reservoir of subclinical HPV in older adults who have HIV infection. Understanding natural history, transmission, and potential implications of oral HPV warrants further investigations.