Biulleten' eksperimental'noi biologii i meditsiny, 1990-01, Vol.109 (1), p.35
1990
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Details
- Autor(en) / Beteiligte
- Titel
- Activation of endogenous lipid peroxidation in the brain in oxidation stress caused by administration of iron and its prevention by vitamin E
- Ist Teil von
- Biulleten' eksperimental'noi biologii i meditsiny, 1990-01, Vol.109 (1), p.35
- Ort / Verlag
- Russia (Federation)
- Erscheinungsjahr
- 1990
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Looking for an appropriate model of accelerated aging in vivo we investigated the content of endogenous products of lipid peroxidation (LP) in the rat brain after single or 4 day-lasting intramuscular injection of complex-bind iron (ferum Hausman, 50 mg/kg body weight) like promoter of LP. We found that the single administration of this iron complex fails to induce endogenous LP; after 4 day-application of iron we observed significant increase in content of primary (lipid peroxides) and final (fluorescent) products of LP. Iron-promoted activation of endogenous LP could be abolished by animal pretreatment with the natural antioxidant alpha-tocopherol. The calcium antagonist nifedipine didn't affect the content of endogenous LP products neither alone nor in combination with alpha-tocopherol.
- Sprache
- Russisch
- Identifikatoren
- ISSN: 0365-9615Titel-ID: cdi_pubmed_primary_2334794
- Format
- –
- Schlagworte
- Administration, Oral, Aging, Animals, Brain - drug effects, Brain - metabolism, Fluorescence, Injections, Intramuscular, Iron - administration & dosage, Iron - pharmacology, Lipid Peroxidation - drug effects, Male, Nifedipine - pharmacology, Oxidation-Reduction, Rats, Stress, Physiological - metabolism, Time Factors, Vitamin E - administration & dosage, Vitamin E - pharmacology