Details

Autor(en) / Beteiligte

• Arzumanyan, Alla
• Reis, Helena M G P V
• Feitelson, Mark A

Titel

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma

Ist Teil von

• Nature reviews. Cancer, 2013-02, Vol.13 (2), p.123-135

Ort / Verlag

England

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. There are few effective treatments partly because the cell- and molecular-based mechanisms that contribute to the pathogenesis of this tumour type are poorly understood. This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC.