Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2012-12, Vol.367 (1607), p.3254-3263
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids
- Ist Teil von
- Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2012-12, Vol.367 (1607), p.3254-3263
- Ort / Verlag
- England
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0962-8436eISSN: 1471-2970DOI: 10.1098/rstb.2011.0384Titel-ID: cdi_pubmed_primary_23108544
- Format
- –
- Schlagworte
- Animals, Arachidonic Acids - antagonists & inhibitors, Arachidonic Acids - metabolism, Cannabinoid Receptor Agonists - metabolism, Cannabinoid Receptor Agonists - pharmacology, Cognition - drug effects, Cognition Disorders - chemically induced, Cognition Disorders - metabolism, Dronabinol - adverse effects, Endocannabinoids - antagonists & inhibitors, Endocannabinoids - metabolism, Glycerides - antagonists & inhibitors, Glycerides - metabolism, Hippocampus - metabolism, Hippocampus - physiopathology, Humans, Memory - drug effects, Neuronal Plasticity, Polyunsaturated Alkamides - antagonists & inhibitors, Polyunsaturated Alkamides - metabolism, Receptor, Cannabinoid, CB1 - metabolism, Synaptic Transmission, TOR Serine-Threonine Kinases - metabolism