Details

Autor(en) / Beteiligte

• Antón-Pérez, Gloria
• Gallego-Samper, Roberto
• Marrero-Robayna, Silvia
• Henríquez-Palop, Fernando
• Rodríguez-Pérez, José C

Titel

Transplantectomy following renal graft failure

Ist Teil von

• Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, Vol.32 (5), p.573

Ort / Verlag

Spain

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Approximately 4%-10% of incident patients on dialysis have a non-functioning kidney graft, and according to series, as many as 32% require transplantectomy for a variety of reasons. Mortality in these patients is significantly higher than in those with a functioning graft or on renal replacement therapy without having received a graft. Graft intolerance syndrome, early graft loss, severe proteinuria, recurring pyelonephritis or neoplasia, and chronic inflammation syndrome have all been proposed as indications for transplantectomy. Chronic inflammation syndrome occurs in patients with high levels of inflammatory markers (C-reactive protein), anaemia resistant to treatment with erythropoiesis stimulators, and malnutrition markers. This inflammatory state is provoked by the graft, and reverts when a transplantectomy is performed, as several studies have shown. We have reviewed the medical literature published on this topic, the indications for transplantectomy and embolectomy, their advantages and disadvantages, the incidence of graft intolerance syndrome, and the pathophysiology of chronic inflammation syndrome, as well as the currently proposed therapeutic management algorithm.