Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (35), p.14236-14240
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Functional convergence of hopanoids and sterols in membrane ordering
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (35), p.14236-14240
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2012
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Liquid-ordered phases are one of two biochemically active membrane states, which until now were thought to be a unique consequence of the interactions between eukaryotic membrane lipids. The formation of a liquid-ordered phase depends crucially on the ordering properties of sterols. However, it is not known whether this capacity exists in organisms that lack sterols, such as bacteria. We show that diplopterol, the simplest bacterial hopanoid, has similar properties and that hopanoids are bacterial “sterol surrogates” with the ability to order saturated lipids and to form a liquid-ordered phase in model membranes. These observations suggest that the evolution of an ordered biochemically active liquid membrane could have evolved before the oxygenation of Earth’s surface and the emergence of sterols.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424, 1091-6490eISSN: 1091-6490DOI: 10.1073/pnas.1212141109Titel-ID: cdi_pubmed_primary_22893685
- Format
- –
- Schlagworte
- Bacteria, Bacteria - metabolism, Bacteria - ultrastructure, Biochemistry, Biological Sciences, Cell Membrane - chemistry, Cell Membrane - metabolism, Cell membranes, Chemical compounds, Cholesterol - chemistry, Cholesterol - metabolism, Cholesterols, Eukaryotes, evolution, Evolution, Molecular, Fluorescence, Gels, hopanoids, Lipid A - chemistry, Lipid A - metabolism, Lipid Bilayers - chemistry, Lipid Bilayers - metabolism, Lipids, Liposomes, Liposomes - chemistry, Liposomes - metabolism, liquid membranes, Liquids, Medicin och hälsovetenskap, Membrane Lipids - chemistry, Membrane Lipids - metabolism, Membranes, Models, Chemical, P branes, Sphingomyelins - chemistry, Sphingomyelins - metabolism, Sterols, Sterols - chemistry, Sterols - metabolism, Terpenes - chemistry, Terpenes - metabolism, Triterpenes - chemistry, Triterpenes - metabolism