Details

Autor(en) / Beteiligte

• Thiel, U
• Wolf, P
• Wawer, A
• Blaeschke, F
• Grunewald, T G P
• von Lüttichau, I T
• Klingebiel, T
• Bader, P
• Borkhardt, A
• Laws, H-J
• Handgretinger, R
• Lang, P
• Schlegel, P G
• Eyrich, M
• Gruhn, B
• Ehninger, G
• Koscielniak, E
• Klein, C
• Sykora, K-W
• Holler, E
• Mauz-Körholz, C
• Woessmann, W
• Richter, G H S
• Schmidt, A H
• Peters, C
• Dirksen, U
• Jürgens, H
• Bregni, M
• Burdach, S

Titel

Human leukocyte antigen distribution in German Caucasians with advanced Ewing's sarcoma

Ist Teil von

• Klinische Padiatrie, 2012-11, Vol.224 (6), p.353

Ort / Verlag

Germany

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Risk stratification criteria for patients with Ewing's sarcoma family of tumors (ESFT) are still limited. We hypothesized divergent human leukocyte antigen (HLA) patterns in ESFT patients and compared HLA-A, -B and -DR phenotype frequencies of patients with advanced ESFT with those of healthy controls. HLA types of all German Caucasian patients with advanced ESFT and available HLA-A, -B and -DR data registered in the European Group for Blood and Marrow Transplantation, Paediatric Registry for Stem Cell Transplantation and the MetaEICESS data bases (study group, n=30) were retrospectively compared with HLA types of healthy German stem cell donors (control group, n=8 862 for single HLA frequencies and n=8 839 for allele combinations). Study group patients had been immuno-typed due to eligibility for allogeneic stem cell transplantation for high risk of treatment failure, and thus constituted a selected subgroup of ESFT patients. After Bonferroni correction for multiple testing (PC), phenotype frequencies of HLA-A24 remained significantly higher in the study group compared to controls (PC<0.05). Furthermore, several HLA combinations were significantly more frequent in the study group compared to controls (all PC<0.05). We report an increased incidence of circumscribed HLA patterns in German Caucasians with advanced ESFT. The possible clinical significance of this observation has to be re-assessed in prospective trials comprising larger ESFT patient numbers of all risk groups.