Details

Autor(en) / Beteiligte

• Scharfstein, Daniel O
• Hogan, Joseph
• Herman, Amir

Titel

On the prevention and analysis of missing data in randomized clinical trials: the state of the art

Ist Teil von

• Journal of bone and joint surgery. American volume, 2012-07, Vol.94 Suppl 1 (Supplement_1), p.80-84

Ort / Verlag

United States

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• We summarize and elaborate on the recently published National Research Council report entitled "The Prevention and Treatment of Missing Data in Clinical Trials." We tailor our discussion to orthopaedic trials. In particular, we discuss the intent-to-treat principle, review study design and prevention ideas to minimize missing data, and present state-of-the-art sensitivity analysis methods for analyzing and reporting the results of studies with missing data.