Details

Autor(en) / Beteiligte

• Li, Min
• Xiong, Ying
• Mu, De-Zhi
• Wang, Hua

Titel

Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation

Ist Teil von

• Zhongguo dang dai er ke za zhi, 2012-07, Vol.14 (7), p.496

Ort / Verlag

China

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This study examined changes to pro-inflammatory cytokine IFN-γ and chemokine IP-10 in the arterial blood of premature infants before and after mechanical ventilation, with the aim of exploring possible mechanisms of ventilation-induced lung injury. Twenty-three neonates requiring mechanical ventilation were enrolled in this study. Arterial blood samples were collected for measuring IFN-γ and IP-10 levels using ELISA before and 4 hours after mechanical ventilation. Blood IFN-γ and IP-10 increased significantly from 59 ± 40 pg/mL and 130 ± 67 pg/mL respectively before mechanical ventilation to 105 ± 54 pg/mL and 220 ± 80 pg/mL respectively after 4 hours of mechanical ventilation (P<0.01). Serum IFN-γ and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.