Details

Autor(en) / Beteiligte

• Maruyama, Tetsuo
• Yoshimura, Yasunori

Titel

Stem cell theory for the pathogenesis of endometriosis

Ist Teil von

• Frontiers in bioscience (Elite edition), 2012-06, Vol.4 (8), p.2754-2763, Article 589

Ort / Verlag

Singapore

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.