Details

Autor(en) / Beteiligte

• DUNLOP, Malcolm G
• DOBBINS, Sara E
• DOMINGO, Enric
• SMILLIE, Claire
• HENRION, Marc
• FRAMPTON, Matthew
• MARTIN, Lynn
• GRIMES, Graeme
• GORMAN, Maggie
• SEMPLE, Colin
• MA, Yusanne P
• BARCLAY, Ella
• FARRINGTON, Susan Mary
• PRENDERGAST, James
• CAZIER, Jean-Baptiste
• OLVER, Bianca
• PENEGAR, Steven
• LUBBE, Steven
• CHANDER, Ian
• CARVAJAL-CARMONA, Luis G
• BALLEREAU, Stephane
• LLOYD, Amy
• VIJAYAKRISHNAN, Jayaram
• JONES, Angela M
• ZGAGA, Lina
• RUDAN, Igor
• THEODORATOU, Evropi
• CONSORTIUM
• STARR, John M
• DEARY, Ian
• KIRAC, Iva
• KOVACEVIC, Dujo
• AALTONEN, Lauri A
• RENKONEN-SINISALO, Laura
• PALLES, Claire
• MECKLIN, Jukka-Pekka
• MATSUDA, Koichi
• NAKAMURA, Yusuke
• OKADA, Yukinori
• GALLINGER, Steven
• DUGGAN, David J
• CONTI, David
• NEWCOMB, Polly
• HOPPER, John
• JENKINS, Mark A
• WHIFFM, Nicola
• SCHUMACHER, Fredrick
• CASEY, Graham
• EASTON, Douglas
• SHAH, Mitul
• PHAROAH, Paul
• LINDBLOM, Annika
• TAO LIU
• SMITH, Christopher G
• TENESA, Albert
• SPAIN, Sarah
• BRODERICK, Peter
• OOI, Li-Yin

Titel

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Ist Teil von

• Nature genetics, 2012-07, Vol.44 (7), p.770-776

Ort / Verlag

New York, NY: Nature Publishing Group

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.