Details

Autor(en) / Beteiligte

• Cui, Wei
• Zhang, Yuanqing
• Xu, Xiaoping
• Shen, Yu-Mei

Titel

Synthesis and 188Re radiolabelling of dendrimer polyamide amine (PAMAM) folic acid conjugate

Ist Teil von

• Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2012-07, Vol.8 (4), p.727-731

Ort / Verlag

Netherlands

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Folic acid receptors (FR) are usually over expressed in many cancer cells and are considered as potential targeted therapy agent. Generation of five polyamido amine (PAMAM) dendrimer folic acid conjugate was synthesised and radiolabelled with (188)Re, furthermore the in vitro/in vivo stability was evaluated accordingly. The labelling yield of the conjugate G5-FA-DTPA-(188)Re was 67.1% and its radiochemical purity exceeded 95%. The conjugate also showed high in vitro stability and potential value for further structure modifications and evaluations.