Details

Autor(en) / Beteiligte

• Mansi, Laura
• Thiery-Vuillemin, Antoine
• Kalbacher, Elsa
• Nguyen, Thierry
• Maurina, Tristan
• Nallet, Jérémie
• Kim, Stefano
• Borg, Christophe
• Kleinclauss, François
• Pivot, Xavier
• Adotevi, Olivier

Titel

Immunotherapy: an emerging strategies against prostate castration resistant cancer

Ist Teil von

• Bulletin du cancer, 2012-07, Vol.99 Suppl 1, p.S57

Ort / Verlag

France

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Castration resistant prostate cancer occurs when patients experience disease progression despite appropriate hormonal manipulations. In these patients, chemotherapy remains standard treatment. Preclinical and clinical data have demonstrated the potential utility of an immunotherapy-based approach for the treatment of prostate cancer (PC). The phase III trial (IMPACT) has recently reported an advantage for Sipuleucel-T over placebo, with an overall survival 4.1 months superior to placebo. Sipuleucel-T is also the first FDA-approved immunotherapy for prostate cancer. These promising results need to be confirmed with other large studies and within previous step of PC. Neoplasic cells can escape immune responses by multiple mechanisms. A better knowledge of these mechanisms is of major concern for the future development of new immunotherapies approach.