Details

Autor(en) / Beteiligte

• Orbetzova, Maria M
• Pehlivanov, Blagovest K
• Mitkov, Mitko M
• Atanassova, Iliana B
• Kamenov, Zdravko A
• Kolarov, Georgi B
• Genchev, Gencho D

Titel

Effect of short-term standard therapeutic regimens on neuropeptide Y and adipose tissue hormones in overweight insulin-resistant women with polycystic ovary syndrome

Ist Teil von

• Folia medica (Plovdiv), 2011-07, Vol.53 (3), p.15

Ort / Verlag

Bulgaria

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The study was aimed at elucidating the influence of a 3-month treatment with routine therapeutic regimens--oral hormonal contraceptives (OHC) with antiandrogenic activity (a standard combination of ethynil estradiol 35 microg plus cyproterone acetate 2 mg) in combination with insulin sensitizing agents--metformin (Group I) and rosiglitazone (Group II) on adipose tissue hormones and hypothalamic neuropeptide Y (NPY) in women with polycystic ovary syndrome. The study included 66 overweight insulin resistant women with PCOS according to the recent ESHRE-ASRM criteria randomized into 2 age-matched therapeutic groups. Significant decrease of leptin (P < 0.01; P = 0.001, resp.), resistin (P < 0.01; P < 0.01, resp.), tumour necrosis factor alpha (TNF alpha) (P = 0.001; P < 0.001, resp.), and NPY (P < 0.05; P < 0.001, resp.) was observed in both groups after treatment. These findings were in parallel with a significant decrease in the anthropometric parameters of body weight in the metformin group only. No significant changes in hormonal characteristics of the groups were found except for a significant decrease in androstenedione and DHEA-S (P < 0.05) in the metformin group and in 17-OH-progesterone (P < 0.05) in the rosiglitazone group. HDL-cholesterol rose and diastolic blood pressure fell significantly (P < 0.05) in the metformin group. Our data suggest beneficial effects of the treatment on potential cardiovascular risk in insulin resistant PCOS women.