Details

Autor(en) / Beteiligte

• Sirotkina, M A
• Elagin, V V
• Subochev, P V
• Denisov, N N
• Shirmanova, M V
• Zagaĭnova, E V

Titel

Laser hyperthermia of tumors with the use of golden nanoparticles under the control of optical coherent tomography and acoustothermometry

Ist Teil von

• Biofizika, 2011-11, Vol.56 (6), p.1142

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The local laser hyperthermia of an experimental tumor RShM-5 of mice with the use of golden plasmin resonance nanoparticles has been carried out. The accumulation of particles in the tumor was controlled by the in vivo noninvasive method of optical coherent tomography. Using this method, the time of the maximum content of nanoparticles in the tumor was determined to be 5 h after the intravenous administration during which the laser hyperthermia was performed. The control of the tumor temperature during the hyperthermia seance showed that the application of nanoparticles provides an effective temperature elevation inside the node and a more targeted heating. The local laser hyperthermia with nanoparticles induced the inhibition of the tumor growth from day 5 to day 7 after the seance with a maximum value of 56%.