Zhonghua gan zang bing za zhi, 2011-08, Vol.19 (8), p.594
2011
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- Autor(en) / Beteiligte
- Titel
- Investigation on the migration and biologic effects of nano FeOx powders under the exposure of extremely low frequency altering electric magnetic field in human heptoma-bearing nude mice in vivo
- Ist Teil von
- Zhonghua gan zang bing za zhi, 2011-08, Vol.19 (8), p.594
- Ort / Verlag
- China
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the mechanism and biologic effects of 37 nm magnetic nano FeOx powders (MNPs) on human hepatoma-bearing nude mice. 37 nm MNPs were prepared by coprecipitation methods and then injected into human hepatoma (Bel-7402) bearing-nude mice through the tail vein. After injection of MNPs, the mice were first exposed under static magnetic field and then treated under extremely low frequency altering-electric magnetic field directing to the tumor area. The migration and trafficking of MNPs were determined by MMR. Tumor growth was monitored with calipers every 5 days and tumor volume was calculated on the basis of three-dimensioned measurements. The apoptosis of tumor cells was analyzed by flow cytometry analysis. The expressions of apoptosis-associated proteins Bcl-2, Bax and HSP27 were determined using western-blot analysis. Static magnetic field could direct the migration and trafficking of MNPs to the tumor site with a higher ratio of 98.9%. Extremely Low Frequency Electric-Magnetic Field (EMF) treatm
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1007-3418DOI: 10.3760/cma.j.issn.1007-3418.2011.08.009Titel-ID: cdi_pubmed_primary_22152316
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - pharmacology, Apoptosis - drug effects, bcl-2-Associated X Protein, Biological Products, Cell Line, Tumor, Cell Proliferation - drug effects, Flow Cytometry, Humans, Magnetic Fields, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Powders, Proto-Oncogene Proteins c-bcl-2