Details

Autor(en) / Beteiligte

• King, Irah L
• Fortier, Anne
• Tighe, Michael
• Dibble, John
• Watts, Gerald F M
• Veerapen, Natacha
• Haberman, Ann M
• Besra, Gurdyal S
• Mohrs, Markus
• Brenner, Michael B
• Leadbetter, Elizabeth A

Titel

Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

Ist Teil von

• Nature immunology, 2012-01, Vol.13 (1), p.44-50

Ort / Verlag

United States

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses.