Details

Autor(en) / Beteiligte

• Novoselov, V I
• Ravin, V K
• Sharapov, M G
• Sofin, A D
• Kukushkin, N I
• Fesenko, E E

Titel

Modified peroxiredoxins as prototypes of drugs a powerful antioxidant

Ist Teil von

• Biofizika, 2011-09, Vol.56 (5), p.873

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• The possibility of using modified peroxyredoxins as powerful antioxidant agents has been considered. Peroxyredoxins immobilized on perfluorocarbon emulsions and PTD-modified peroxyredoxins have been studied. It has been shown that peroxyredoxins efficiently bind to particles of perfluorocarbon emulsions, while maintaining their antioxidant properties. A panel of PTD-modified peroxyredoxins has been created and peroxyredoxins most effective both in antioxidant properties and the ability to penetrate cells have been selected. The modified peroxyredoxins obtained may serve as the basis for the design of drug with powerful antioxidant action.