Zhongguo zhongyao zazhi, 2011-06, Vol.36 (12), p.1650
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Protective effect of hydroxysafflor yellow A on endothelial cell injury induced by lipopolysaccharide
- Ist Teil von
- Zhongguo zhongyao zazhi, 2011-06, Vol.36 (12), p.1650
- Ort / Verlag
- China
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To observe the protective effect of hydroxyl safflor yellow A (HSYA) on endothelial cell (EC). It has been observed by RT-PCR that HSYA can inhibit the elevation of TNF-alpha, IL-6, ICAM-1 and VCAM-1 mRNA level induced by LPS. The result of immunofluorescence test suggested that HSYA can alleviate p65 subgroup of NF-kappaB nuclear translocation. The experiment on EA-HY926 cell line proved that HSYA can protect EC against inflammation injury.
- Sprache
- Chinesisch; Englisch
- Identifikatoren
- ISSN: 1001-5302DOI: 10.4268/cjcmm20111224Titel-ID: cdi_pubmed_primary_22007554
- Format
- –
- Schlagworte
- Cell Line, Chalcone - analogs & derivatives, Chalcone - pharmacology, Endothelial Cells - drug effects, Endothelial Cells - metabolism, Humans, Intercellular Adhesion Molecule-1 - metabolism, Interleukin-6 - metabolism, Lipopolysaccharides - toxicity, NF-kappa B - metabolism, Quinones - pharmacology, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha - metabolism, Vascular Cell Adhesion Molecule-1 - metabolism