Zhongguo Zhong xi yi jie he za zhi, 2011-06, Vol.31 (6), p.803
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of scutellaria stem-leaf total flavonoids on cardiocyte apoptosis induced by hypoxia/reoxygenation
- Ist Teil von
- Zhongguo Zhong xi yi jie he za zhi, 2011-06, Vol.31 (6), p.803
- Ort / Verlag
- China
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To study the effect of Scutellaria baicalensis stem-leaf total flavonoids (SSTF) on cardiocyte apoptosis of neonatal rats induced by hypoxia/reoxygenation and its action of mechanism. METHODS Sixty one to two days old rats, male or female, were selected. Hypoxia/reoxygenation injured model was established in cultured cardiocytes of neonate rats. The cultured neonatal rat cardiocytes were divided into 5 groups, i.e., the normal control group, the hypoxia/reoxygenation injury group (as the model group, cultured cardiocytes were exposed to hypoxia 2 h and subsequently reoxygenated for 4 h), the hypoxia/reoxygenation injury plus 50 mg/L SSTF group (as the low dose SSTF group), the hypoxia/reoxygenation plus 100 mg/L SSTF group (as the middle dose SSTF group), and the hypoxia/reoxygenation plus 200 mg/L SSTF group (as the high dose SSTF group). The cell viability was detected by methyl thiazolyl tetrazolium (MTT) colorimetry. The apoptosis of cardiocytes was determined by terminal deoxynucleotidyl transferase-medi
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1003-5370Titel-ID: cdi_pubmed_primary_21823428
- Format
- –
- Schlagworte
- Animals, Apoptosis - drug effects, bcl-2-Associated X Protein - metabolism, Cell Hypoxia - drug effects, Cells, Cultured, Female, Flavonoids - pharmacology, Male, Myocytes, Cardiac - drug effects, Myocytes, Cardiac - metabolism, Plant Stems - chemistry, Proto-Oncogene Proteins c-bcl-2 - metabolism, Rats, Rats, Sprague-Dawley, Scutellaria - chemistry